Recording force events of single quantum-dot endocytosis.
نویسندگان
چکیده
We applied force spectroscopy based on atomic force microscope (AFM) to demonstrate the possibility of measuring the interaction force between single quantum-dots (QDs) and living cells at single particle level under native conditions. In the force-distance cycle, we recorded the events of cellular uptake of single QDs and single QD detachment from the cell.
منابع مشابه
Propranolol Restricts the Mobility of Single EGF-Receptors on the Cell Surface before Their Internalization
The epidermal growth factor receptor is involved in morphogenesis, proliferation and cell migration. Its up-regulation during tumorigenesis makes this receptor an interesting therapeutic target. In the absence of the ligand, the inhibition of phosphatidic acid phosphohydrolase activity by propranolol treatment leads to internalization of empty/inactive receptors. The molecular events involved i...
متن کاملQuantum current modeling in nano-transistors with a quantum dot
Carbon quantum dots (CQDs) serve as a new class of ‘zero dimensional’ nanomaterial’s in thecarbon class with sizes below 10 nm. As light emitting nanocrystals, QDs are assembled from semiconductormaterials, from the elements in the periodic groups of II-VI, III-V or IV-VI, mainly thanks to impacts of quantum confinement QDs have unique optical properties such as brighter, highly pho...
متن کاملRecording the dynamic endocytosis of single gold nanoparticles by AFM-based force tracing.
We utilized force tracing to directly record the endocytosis of single gold nanoparticles (Au NPs) with different sizes, revealing the size-dependent endocytosis dynamics and the crucial role of membrane cholesterol. The force, duration and velocity of Au NP invagination are accurately determined at the single-particle and microsecond level unprecedentedly.
متن کاملBistability in the Electric Current through a Quantum-Dot Capacitively Coupled to a Charge-Qubit
We investigate the electronic transport through a single-level quantum-dot which is capacitively coupled to a charge-qubit. By employing the method of nonequilibrium Green's functions, we calculate the electric current through quantum dot at finite bias voltages. The Green's functions and self-energies of the system are calculated perturbatively and self-consistently to the second order of inte...
متن کاملModeling of High Temperature GaN Quantum Dot Infrared Photodetectors
In this paper, we present calculations for different parameters of quantum dot infrared photodetectors. We considered a structure which includes quantum dots with large conduction-band-offset materials (GaN/AlGaN). Single band effective mass approximation has been applied in order to calculate the electronic structure. Throughout the modeling, we tried to consider the limiting factors which dec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 47 12 شماره
صفحات -
تاریخ انتشار 2011